James E Krause Selected Research

N,N- bis(1,3- benzodioxol- 5- ylmethyl)- 1- butyl- 2,4- diphenyl- 1H- imidazole- 5- methanamine

12/2008

Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist.

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James E Krause Research Topics

Disease

7	Pain (Aches) 08/2010 - 01/2005
3	Hyperalgesia 08/2010 - 12/2008
2	Inflammation (Inflammations) 12/2008 - 12/2005
1	Macular Degeneration (Age-Related Maculopathy) 01/2009
1	Edema (Dropsy) 12/2008
1	Hypersensitivity (Allergy) 12/2008
1	Neutropenia 12/2008
1	Obesity 06/2008
1	Ganglion Cysts (Ganglion) 12/2006

Drug/Important Bio-Agent (IBA)

3	CarrageenanIBA 08/2010 - 12/2008
2	Freund's AdjuvantIBA 08/2010 - 04/2010
2	TRPV Cation ChannelsIBA 08/2007 - 01/2005
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2009
1	Anaphylatoxin C5a ReceptorIBA 01/2009
1	benzamideIBA 12/2008
1	N,N- bis(1,3- benzodioxol- 5- ylmethyl)- 1- butyl- 2,4- diphenyl- 1H- imidazole- 5- methanamineIBA 12/2008
1	LipopolysaccharidesIBA 12/2008
1	Interleukin-6 (Interleukin 6)IBA 12/2008
1	compound 18IBA 08/2008
1	RimonabantIBA 06/2008
1	cinnamaldehyde (cinnamic aldehyde)FDA Link 08/2007
1	Menthol FDA Link 08/2007
1	gingerolIBA 08/2007
1	NeuropeptidesIBA 12/2006
1	AnaphylatoxinsIBA 12/2005
1	Purinergic Receptors (Receptors, Purine)IBA 10/2005
1	Ion Channels (Ion Channel)IBA 01/2005

Therapy/Procedure

2	Oral Administration 08/2010 - 04/2010
1	Ligation 12/2008
1	Therapeutics 01/2005